Harry-Potter20/Vigil

Pharmacovigilance intelligence for clinicians. Safety signals, DDI, patient-specific dosing, PGx, and Africa formulary status (NAFDAC · SAHPRA · WHO) — any drug, under 60 seconds. Built by TIBA Health. # Vigil **Know before you prescribe.** Pharmacovigilance intelligence for clinicians — drug safety signals, interactions, dosing, and Africa formulary status. Any drug. Any patient. Under 60 seconds. --- ## What it does Type a drug name. Vigil scans 11M+ biomedical papers and live regulatory sources, then returns: - **Safety signals** — severity-classified, evidence-rated, source-cited - **Rising signal detection** — publication velocity tracking (30-day vs 6-month) - **Trial cross-reference** — active ClinicalTrials.gov studies flagged against signals - **Safety scorecard** — therapeutic alternatives scored /100 - **Drug-drug interactions** — severity-ranked with mechanism and management - **Dosage calculator** — patient-specific dose with renal, hepatic, BSA, weight adjustments - **Special populations** — pregnancy, lactation, geriatric, paediatric flags - **Pharmacogenomics** — CYP2D6, CYP2C19, HLA-B, TPMT gene-drug interactions - **Africa formulary** — NAFDAC, SAHPRA, WHO prequalification status - **PDF clinical brief** — one-click export of all findings --- ## Architecture ``` Paperclip → 11M+ papers, 225K+ FDA docs, 580K+ trials (semantic search) ScraperAPI → Live: WHO alerts, NAFDAC, SAHPRA Groq / Llama → Signal extraction, DDI, dosing, PGx, Africa formulary Streamlit → Editorial UI — dark/light mode, 8-tab dashboard fpdf2 → PDF clinical brief export ``` --- ## Quickstart ```bash git clone github.com cd vigil pip install -r requirements.txt cp .env.example .env # Add your keys: PAPERCLIP_API_KEY, GROQ_API_KEY, SCRAPERAPI_KEY streamlit run ui/app.py ``` --- ## Demo **Try it live:** vigil.streamlit.app **Demo search:** `semaglutide` + co-medication `warfarin` - 3 critical signals including thyroid C-cell tumour (rising signal — medRxiv x3.5) - 12 active trials flagged, 3 marked immediate review - Tirzepatide 70/100 vs semaglutide 55/100 - DDI: delayed absorption, monitor INR - Renal-adjusted …