ilariapola/Plasma-proteomic-profiles-of-Alzheimer-s-Disease-and-Neurodegeneration-in-African-Cohorts

Sample R code from Nature Communications paper on plasma proteomics and Alzheimer's disease pathology in African cohorts # Sample R code from Nature Communications "Plasma proteomic profiles of Alzheimer's Disease and Neurodegeneration in African Cohorts" This repository contains the R scripts used to reproduce the main analyses and figures presented Structure: ### Demographics Generation of demographic tables and descriptive statistics. ### Volcano_plots Differential protein expression analyses: - Amyloid-positive versus amyloid-negative participants. - Cognitively impaired versus cognitively unimpaired participants within amyloid strata. ### Stacked histograms Stacked bar plots showing the relative composition of functional protein categories among significantly altered proteins. ### Comorbidities analysis Linear regression analyses assessing associations between grouped comorbidities and plasma protein levels ### LOESS Protein trajectory visualizations across disease stages using z-scored protein concentrations relative to the CU- reference group. ## Software R statistical software version 4.4.0. Main packages: - dplyr - tidyr - purrr - broom - ggplot2 - ggrepel - gprofiler2 - table1 ## License MIT License.