kiraels/plos_med_2026

Code release corresponding to PLOS Medicine manuscript "Point-of-care early infant diagnosis at birth in a pragmatic cluster-randomized trial in Mozambique and Tanzania: A comparative cost and cost-effectiveness study" # Point-of-care early infant HIV diagnosis at birth in a pragmatic cluster-randomized trial in Mozambique and Tanzania: A comparative cost and cost-effectiveness study ** Code release corresponding to PLOS Medicine manuscript ** Kira Elsbernd, Issa Sabi, Ilesh V. Jani, Chishamiso Mudenyanga, Siriel Boniface, Arlete Mahumane, Joaquim Lequechane, Falume Chale, Bindiya Meggi, Kassia Pereira, Raphael Edom, Anange F. Lwilla, W. Chris Buck, Nyanda Elias Ntinyinya, Michael Hoelscher, Till Baernighausen, Arne Kroidl, Stefan Kohler. Comparative cost and cost-effectiveness of point-of-care early infant HIV diagnosis at birth: Findings from a pragmatic cluster-randomized trial in Mozambique and Tanzania. PLOS Medicine 2026. ** DOI **: 10.5281/zenodo.14959301 ## Overview - Data preprocessing for costs and effectiveness outcomes - Descriptive costs (unit cost per test and per infant) and effectiveness outcomes (ART initiation in the first week of life and EID test within the first 8 weeks of life) - Incremental costs, incremental effectiveness, and ICERs estimated using Bayesian hierarchical models and hesim:: - Required life-years benchmark for cost-effectivness calculation - One way sensitivity for cost per test - Sensitivity analysis of intrauterine transmission influence on ICER - Figures NOTE: some datasets link sensitive individual-level cost and health outcome data and are not publicly available due to confidentiality. ## Usage Run from main.R Add user-specific paths to copy of /config/paths_template.R Scripts that are commented out are not runnable with publicly available data but are provided for documentation purposes. ## Contact elsbernd.kira@med.uni-muenchen.de