sayalaruano/NTDs2RDF

The NTDs2RDF project aimed to create a schema and an RDF graph of proteins, metabolic pathways, drugs, and other relevant data for three NTDs (Chagas disease, leishmaniasis, and African trypanosomiasis) to integrate all the information in a single data structure that can be queried to obtain novel therapeutic insights. NTDs2RDF A heterogeneous and integrated knowledge graph for the exploration of neglected tropical diseases ## Table of contents: - About the project - How to run the web app locally? - Structure of the repository - Credits - Further details - Contact ## About the project [Neglected tropical diseases (NTDs)][ntds] are a **heterogeneous group of 20 bacterial, viral, parasitic, and fungal conditions** that generally occur in **developing tropical countries** in the Americas, Africa, and Asia. NTDs mainly affect poor populations that do not have access to safe water, sanitation, and high-quality healthcare. Because of the severe effects of NTDs (i.e., they can cause long-lasting disabilities), they **reinforce the cycle of poverty** in vulnerable communities. Currently, there are several independent databases that contain information about proteins, metabolic pathways, and drugs involved in NTDs, but no integrated databases with all the information. This **unified resource** could enable the **systematic exploration of all the components of the NTDs**, contributing to the research of potential therapies for these diseases. The **NTDs2RDF** project aimed to create **a knowledge graph (KG) of genes, proteins, metabolic pathways, gene ontologies, single nucleotide variants, drugs**, and other relevant data for **three NTDs (Chagas disease, leishmaniasis, and African trypanosomiasis)**, integrating all the information in a single data structure that can be explored through a query interface implemented with a [Streamlit][streamlit] **web application**. This software provides a user-friendly platform to extract information from the KG using **SPARQL queries**. An overview of the workflow of this project is shown in the graphical abstract below. Figure 1. Graphical abstract of the NTDs2RDF workflow. The project represents an initial step towards the creation of a heterogeneous database for different NTDs with several potential applications in …