Haplotype bifurcation diagrams and extended haplotype homozygosity plots of HbC, HbS and HbA core haplotypes.
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healthcareType de record:
Figures 3A and 3B describe the haplotype bifurcation diagrams for each core haplotype at HbC, HbS and HbA in the healthy control and simulated haplotype data respectively from the KND-Ghana. The diagrams demonstrate the extent of homozygosity in haplotypes. Diagrams one, two and three within each Figure represent HbA, HbC and HbS haplotypes respectively. Figures 3C and 3D are the extended haplotype homozygosity (EHH) plots around the core HbS/HbC loci in the healthy control and simulated haplotype data respectively. EHH scale ranges from 0 to 1: (0 implying no homozygosity, all extended haplotypes are different and 1 complete homozygosity, all extended haplotypes are the same). The green plot represents the EHH signal around the HbS locus. The orange plot represents the EHH signals around the HbC locus. And the red plot represents the lack of a pronounced EHH signal around the HbA locus.