Abstract In Africa, the work experiences of disabled people can help employers and the government build more inclusive workplaces. Nonetheless, research exploring disabled people's work experiences at various employment stages is limited, particularly in Africa. The study applies ethnographic research methods to examine the work experience of those with visual, speech, hearing, mobility and psychological disabilities in Ghana. Data were coded and analysed using content and descriptive methods. The findings suggest that disabled people face several barriers, including inadequate accommodation, negative stereotyping, stigmatization, discrimination and poor performance evaluation at work. This paper argues that transformational leadership is a prerequisite for African governments and private sector employers seeking to improve the workplace environment and build an inclusive culture within these spaces.