All runs assume the RTS,S vaccine is 50% efficacious and has a half-life of 3 years. PEV at EPI denotes the pre-erythrocytic vaccine being given through the Expanded Program on Immunization, whilst mass PEV denotes a mass vaccination campaign. All runs include LLINs. (A) PEV at EPI with or without additional MSAT in Kjenjojo, Uganda (B) Mass PEV with or without additional MSAT in Kjenjojo, Uganda (C to F) MSAT and IRS with mass PEV in: (C) Kinkole, DRC, (D) Maputo, Mozambique, (E) Nkoteng, Cameroon and (F) KND, Ghana.