This study investigated the impact of the Digital Mathematics laboratory on senior secondary school students’ development of entrepreneurship skills. The study adopted a descriptive research design, three research questions were raised and a research hypothesis was developed with a sample of 300 senior secondary school II students and 40 mathematics teachers, which were all purposively selected. Two instruments were used for data collection; the instruments were validated, and reliability indexes were obtained. The data collected were analyzed using mean, standard deviation while the hypothesis was tested using t-test at a significance level of 0.05 level. The findings of the study revealed that the Digital Mathematics Laboratory helped students develop entrepreneurship skills, and gender did not influence the impact of the digital mathematics laboratory. Hence, it was recommended that mathematics teachers should be trained in the use of digital mathematics laboratories to help students develop entrepreneurship skills