This study aims to explore the challenges facing the perception of women entrepreneurs in the Bole Hora town administration, Ethiopia, Horn of Africa. Related to the challenges faced in the perception, attitude, and belief of women entrepreneurs, in-action and the potential women are segregated. The researchers used a qualitative research design related to the interpretative approach. The researchers interviewed eight women entrepreneurs involved in the venture start-up. The purposive sampling technique was used to get primary data from the respondent with the help of a structured interview. For qualitative data analysis, the thematic data analysis method was used. The major findings of the study showed that challenges faced by the women entrepreneurs in the study area were lack of finance, working place, training, and social-cultural factors. The implication of the study will help the government to revise its policy to give a solution to individual and organizational–related, legal/administration, economic, social/cultural, and other factors that affect the perception of women entrepreneurs about entrepreneurial activity.