The study empirically examined job design dimensions and performance of manufacturing firms in Nigeria, a study of Calabar Municipality in Cross River State The specific objectives were to determine the relationship between job description, job specification, employees’ initiative and employee satisfaction, product quality and sales volume. The study adopted a correlational research design. A sample of two hundred and sixty-six (266) questionnaire was administered to respondent from a population of seven hundred and ninety-four (794), two hundred and forty-five copies were correctly filled and returned. Data from this study were gathered from primary sources with the aid of structured questionnaire. Pearson Product moment correlation (PPMC) was used to test the hypotheses at 0.05 level of significance. The findings revealed that job description, job specification and employees’ initiative had a significant relationship with employee satisfaction, product quality and sales volume of the manufacturing firms. The study recommended that the managers of the selected manufacturing firms in Calabar, Cross River State should ensure that jobs are described and assigned to the right person, at the right time by giving detailed information about the duties and responsibilities to be carried out by the job holder thereby enhancing employees’ satisfaction. Also, managers should design jobs that provide avenues for employees to plan, organize and control positions of their jobs by involving them in the decisions as to how and when a job should be designed to enhance performance