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Linking cerebral malaria pathogenesis to APOE-mediated amyloidosis

Domaine:

healthcare

Type de record:

paper
Créateur:
MwiShaJamJam
Éditeur:
Res
Hôte:
Abstract Although most children with cerebral malaria fully recover, about a fifth of the survivors develop post-discharge neurodevelopmental sequelae suggestive of advanced neuronal injury. However, the cerebral molecular processes initiating neurological dysfunction in cerebral malaria are still debatable. In this article, we explore available data and hypothesise that cerebral malaria might be linked to APOE-mediated amyloidosis, the primary pathological process that initiates neurodegeneration in Alzheimer's disease. If our hypothesis is tested and found to be true, it could have far-reaching implications for what we know about cerebral malaria pathogenesis.

Visit

doi.org

Licenses

https://creativecommons.org/licenses/by/4.0/

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