Educational inequality in Nigeria persists due to the interplay of socio-economic, cultural, and institutional factors that shape students’ access, learning outcomes, and psychological well-being. Drawing on Bronfenbrenner’s Ecological Systems Theory, this study analyses how nested environmental layers from immediate home-school interactions to broader cultural norms, policies, and temporal changes produce systemic disparities in Nigerian education. A qualitative content analysis of secondary literature was conducted to map mesosystemic failures, exosystemic influences such as funding and employment stability, macrosystemic effects of gender norms and ethnicity, and chronosystemic impacts of economic and political instability. Findings reveal that household poverty, hidden schooling costs, geographic disparities, gender norms, religious interpretations, language barriers, and low family literacy collectively limit enrolment, retention, and attainment, particularly for girls, rural learners, and marginalised groups. These inequalities are further linked to heightened psychological distress, anxiety, and reduced academic engagement. The study concludes that addressing educational inequality requires a holistic strategy that strengthens home-school collaboration, expands inclusive and equitable resourcing, and integrates mental health support, and reforms cultural and policy barriers. Recommendations emphasise targeted funding, mother-tongue instruction, community engagement, and psychosocial services to promote equitable, inclusive education and support both learning and well-being in Nigeria.