Since the advent of patent protection, the territoriality of patent has threatened the effectiveness of patent protection globally. This issue has given rise to an innovative system known as the ‘Unitary Patent System’. This system is only operational under three jurisdictions worldwide, the Gulf Cooperation Council Patent Office, the European Union, and the Organisation Africaine de la Propriété Intellectuelle. This study focuses on the latter two. This study examine the existing patent systems in the European Union and the Organisation Africaine de la Propriété Intellectuelle and served a comparative analysis, focusing on the European trends that could be adopted by Organisation Africaine de la Propriété Intellectuelle and the possibility of unifying efforts across Africa. This study adopted the doctrinal research methodology to arrive at its postulations. This study found that, even though the Unitary Patent System is existent in Africa, only a small fraction of African states (particularly the participating member states of the OAPI which are all francophone states) benefit from this system. Also, this study found that though the system is functioning in Africa, there are still a couple of lacunae and shortcomings which need to be rectified. This study concluded that there is a need to concentrate on the reformation of the system as a whole through introduction of substantive examination, provision of additional incentives for innovation, reinforcing international cooperation, revisiting competence of national courts, as well as encouraging harmonising efforts between Intellectual Property Organisations regarding patent protection.