This study aims to map the available evidence on feasibility of implementing Pharmacist prescribing at PHC level in Lesotho. This evidence will be captured from LMICs and HICs as there is currently limited data available in Lesotho. The evidence from literature will be synthesized to chart Pharmacist prescribing (PP) models, barriers and facilitators and to access the reported outcomes. Additionally, this evidence will help underpin gaps in development of regulatory framework that will be tailored to Lesotho's context in order to ease integration of PP.