
District hospitals in Nigeria face challenges in delivering optimal healthcare services, impacting patient outcomes and system efficiency. A mixed-method approach combining quantitative data from surveys with qualitative insights from interviews will be employed. Multilevel regression analysis will assess various system-level and individual-level predictors of healthcare performance. The preliminary findings indicate that patient adherence to treatment protocols significantly correlates with improved health outcomes, suggesting a need for enhanced compliance strategies. This research protocol underscores the importance of multifaceted interventions in improving healthcare delivery at district hospitals in Nigeria. Strategies should focus on enhancing patient education and engagement alongside system-level reforms to optimise yield improvement. district hospitals, Nigeria, multilevel regression analysis, healthcare performance, yield improvement Treatment effect was estimated with $\text{logit}(p_i)=\beta_0+\beta^\top X_i$, and uncertainty reported using confidence-interval based inference.