As a refinement to MIDLIFE IN THE UNITED STATES (MIDUS II), 2004-2006 (ICPSR 4652), a sample of African Americans from Milwaukee was included to examine health issues in minority populations. Areas of the city of Milwaukee, Wisconsin, were stratified according to the proportion of the population that were African American. Those areas with high concentrations were sampled at higher rates than areas with lower concentrations. Area probability sampling methods were used along with population counts from the 2000 United States Census to identify potential respondents. Field interviewers screened households to determine if they contained any African American adults. There was additional screening to achieve an appropriate age/gender distribution in a manner similar to what was done for the original MIDUS sample (NATIONAL SURVEY OF MIDLIFE DEVELOPMENT IN THE UNITED STATES (MIDUS), 1995-1996 [ICPSR 2760]). Milwaukee respondents were interviewed in their homes using a Computer Assisted Personal Interview (CAPI) protocol and afterwards asked to complete a Self-Administered Questionnaire (SAQ). All measures paralleled those used in the larger MIDUS I and II samples. After successful completion of the Project 1 survey, some participants were eligible to participate in other MIDUS projects (2 through 5). Survey data was collected for 592 individuals. Response Rates: The overall response rate for the in-person interview was 70.7 percent. The overall SAQ response rate was 67.2 percent. The phone survey administration of the Telephone Assisted Cognitive Testing (TACT) had an overall response rate of 51.8 percent. Full discussion of the response rates for all of these portions of the MIDUS II Project 1 Milwaukee oversample are reported in the response rates section of Appendix A. The sampling design was a stratified area probability sample of households in Milwaukee County, Wisconsin. The sampling frame included Census tracts in which at least 40 percent of the population was African American. The Census blocks were stratified by income, with roughly half coming from tracts in which the median household income was $40,000 or greater, and the rest coming from tracts in which the median household income was below $40,000. Datasets: DS1: Midlife in the United States (MIDUS 2): Milwaukee African American Sample, 2005-2006 Adult African American residents aged 25-74 in Milwaukee, Wisconsin. Smallest Geographic Unit: city computer-assisted personal interview (CAPI); computer-assisted telephone interview (CATI); face-to-face interview; mail questionnaire; telephone interviewThe title of this study was changed from Midlife Development in the United States (MIDUS II): Milwaukee African American Sample, 2005-2006, to Midlife in the United States (MIDUS 2): Milwaukee African American Sample, 2005-2006, on June 2, 2017.Additional information about the Midlife Development in the United States study can be found at the MIDUS website.