This study addresses the significant barriers to effective dialysis treatment faced by South African patients with Chronic Kidney Disease (CKD), a condition affecting an estimated 6.4% to 17.3% of the population, with a disproportionate impact on poorer communities due to socioeconomic disparities and limited healthcare access. The absence of portable and compact Automated Peritoneal Dialysis (APD) systems, particularly in remote areas, severely restricts patient mobility and quality of life. To mitigate these challenges, the Miniature Digitalized Ubuntu APD machine (i.e. lightweight and portable) is developed. It integrates sorbent-based dialysate regeneration technology and digital health features. The research framework employed a multi-disciplinary approach, combining expertise from biomedical and electrical engineering. The main methods involved designing and simulating the APD system, which includes patient-centric features for monitoring, collecting, and optimizing treatment parameters. Key health metrics such as patient vital signs, biochemical markers, and patient-reported outcomes are continuously monitored. The results indicate that the system significantly improves patient outcomes by enhancing treatment efficacy and reducing healthcare costs. The use of sorbent-based dialysate regeneration technology minimizes logistical challenges associated with dialysate transportation and reduces the volume of fluids needed, making the system more environmentally friendly and cost-effective. Thus, this machine has the potential to substantially improve the quality of life and treatment outcomes for CKD patients in South Africa, thereby reducing the burden on healthcare facilities. This innovative device empowers patients through a user-friendly and portable solution, contributing to the sustainability and effectiveness of dialysis treatment.