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Molecular Characterization of Candida Species Among HIV/AIDS Patients Attending General Hospital, Azare, Bauchi State, Nigeria

Domaine:

healthcare

Type de record:

paper
Créateur:
AbbSalAmiAbu
Éditeur:
Uma
Hôte:
Candida albicans are opportunistic fungal pathogens among immunocompromised individuals, particularly patients living with HIV/AIDS.  This study investigated Candida albicans among HIV/AIDS patients attending General Hospital Azare, Bauchi State, Nigeria.  A hospital-based cross-sectional study was conducted among 250 HIV-positive patients receiving antiretroviral therapy between October 2024 and April 2025, where Oral swab samples were collected and processed.  Presumptive identification was carried out using Sabouraud Dextrose Agar, CHROMagar Candida, germ tube test, and cornmeal agar morphology.  Molecular confirmation was performed using Polymerase Chain Reaction targeting the Internal Transcribed Spacer (ITS1–ITS4) region.  The PCR products were sequenced and analyzed using BLAST.  Out of 250 samples analyzed, 27 Candida isolates were identified, of which Candida albicans accounted for 18 (66.7%).  The findings demonstrate the superiority of molecular techniques over conventional phenotypic methods for accurate fungal identification.  Molecular diagnostics should therefore be integrated into routine management of oral candidiasis among HIV/AIDS patients.

Languages

Bauchi

Licenses

https://creativecommons.org/licenses/by-nc/4.0

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