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MR1-restricted T-cell clonotypes are associated with 'resistance' to Mycobacterium Tuberculosis infection - TRA/D immunoSEQ

Domaine:

healthcare

Type de record:

dataset
Créateur:
CroSes
Éditeur:
Zenodo
Hôte:avatar
Summary Number of files: 39 Data format: tsv Data type: TCRA/D immunoSEQ (Adaptive Biotechnologies) immunoSEQ version: v2 Sample type: peripheral blood mononuclear cells (PBMCs) Genomic DNA extraction protocol: QIAGEN DNeasy Blood and Tissue kit Sample description Peripheral blood samples were collected from participants enrolled in a longitudinal cohort study based in Uganda. Donors were classified as either "resistors" (RSTRs, n = 19, defined as concordantly negative for tuberculin skin test and IFNg release assay despite high environmental exposure) or latently infected with M. Tuberculosis (LTBI, n = 20, concordantly as longitudinally positive for tuberculin skin test and IFNg release assay). Genomic DNA (gDNA) was extracted from cryopreserved PBMCs without stimulation or enrichment of T-cells using the Quiagen DNeasy Blood and Tissue kit. Protocol can be found at: qiagen.com 

Tags

ImmunologyFOS: Clinical medicine

Licenses

Creative Commons Attribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/legalcode

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