The concept of open access has opened up access to scholarly communication. Academia today can publish and have access to a cocktail of information resources without restrictions and without paying anything. This chapter seeks to explain open access to scholarly communication and its future in Sub-Saharan Africa. The chapter begins by explaining the concept of open access, various forms of open access publishing, benefits of open access, and a brief history of open access to scholarly communication in Sub-Saharan Africa. The chapter also highlights some notable open access initiatives that have been implemented in Sub-Saharan Africa in the quest to improve access to scientific research findings in order to accelerate economic development. Furthermore, the chapter catalogues some challenges being encountered in the promotion of open access in Sub-Saharan Africa. Lastly, the chapter predicts the future of open access to scholarly communication in Sub-Saharan Africa, based on the current happenings in this sector.