Nigeria faces significant challenges in managing its escalating municipal solid waste amid rapid urbanization and infrastructural deficits. This paper develops optimization models tailored to waste-to-energy conversion systems that align with circular economy principles to enhance resource recovery and sustainable energy generation. Integrating theoretical foundations of circular economy and advanced optimization techniques, the study identifies key objectives, including cost reduction, emissions mitigation, and energy maximization, and incorporates technical, economic, environmental, and social constraints. The models provide a systematic framework for decision-making that supports the selection of appropriate technologies, resource allocation, and operational planning. Implementation considerations highlight critical technical, infrastructural, policy, and socioeconomic challenges that must be addressed to scale pilot initiatives into sustainable, large-scale systems. The findings underscore the strategic importance of optimization-based approaches in advancing Nigeria's circular economy and energy policy goals, offering actionable recommendations for policymakers, practitioners, and researchers. This research contributes to bridging gaps between theoretical modeling and practical application, fostering environmentally sound and economically viable waste-to-energy solutions that promote sustainable development in emerging economies.