Predicting chronic responses to calcium channel blockade with a virtual population of African Americans with hypertensive chronic kidney disease

Supplementary Material

Supplementary Figure S1. Equations and model parameters for calculating glomerular filtration rate and nephron injury

Supplementary Figure S2. Responses to 3 year calcium channel blockade (CCB), ACE inhibition, and/or lowering salt intake (90 mmol Na+/day) in systemic pressure glomerular filtration rate (GFR), and left ventricular mass. C indicates control simulation without any treatment for 3 years.

Supplementary Figure S3. Acute changes in glomerular filtration rate after initiation of amlodipine (10mg/day) in virtual population (n=165)

Supplementary Figure S4. Determinants of renal vasculature: afferent and efferent arteriolar conductance

Supplementary Figure S5. Determinants of proximal tubular sodium reabsorption

Supplementary Figure S6. Determinants of loop of henle sodium reabsorption

Supplementary Figure S7. Determinants of distal tubular sodium reabsorption

Supplementary Figure S8. Determinants of collecting duct sodium reabsorption

Supplementary Figure S9. Determinants of total body water and balance between body fluid compartments

Supplementary Figure S10. Determinants of renin secretion and macula densa signal

Supplementary Figure S11. Determinants of tubuloglomerular feedback

Supplementary Figure S12. Peripheral blood flow and determinants of organ conductances in the model