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Pseudogene-derived small interference RNAs regulate gene expression in African <i>Trypanosoma brucei</i>

Domaine:

healthcare
Créateur:
YanLinJiaMin
Éditeur:
Nat
Hôte:
Pseudogenes have been shown to acquire unique regulatory roles from more and more organisms. We report the observation of a cluster of siRNAs derived from pseudogenes of African Trypanosoma brucei using high through-put analysis. We show that these pseudogene-derived siRNAs suppress gene expression through RNA interference. The discovery that siRNAs may originate from pseudogenes and regulate gene expression in a unicellular eukaryote provides insights into the functional roles of pseudogenes and into the origin of noncoding small RNAs.

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