A study comparing the public health epidemiology of people living with HIV presenting with and without tuberculosis (TB) in South Africa and Switzerland. To address this research question, we will analyze data from two cohorts, namely the Western Cape Cohort of the International epidemiology Databases to Evaluate AIDS (IeDEA; South Africa) and the Swiss HIV Cohort Study (SHCS; Switzerland). We will compare the outcomes of patients on different ART and TB regimens, including those who are co-infected with TB and those who are not. We will also explore the differences in outcomes between TB patients in the two countries.