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Public Health Impact After the Introduction of PsA-TT: The First 4 Years

Domaine:

healthcare

Type de record:

paper
Créateur:
DioDjiDauNov
Éditeur:
CenWorCenNor
Éditeur:
CCSDOxf
Hôte:avatar
International audience Background. During the first introduction of a group A meningococcal vaccine (PsA-TT) in 2010–2011 and its rollout from 2011 to 2013, >150 million eligible people, representing 12 hyperendemic meningitis countries, have been vaccinated.Methods. The new vaccine effectiveness evaluation framework was established by the World Health Organization and partners. Meningitis case-based surveillance was strengthened in PsA-TT first-introducer countries, and several evaluation studies were conducted to estimate the vaccination coverage and to measure the impact of vaccine introduction on meningococcal carriage and disease incidence.Results. PsA-TT implementation achieved high vaccination coverage, and results from studies conducted showed significant decrease of disease incidence as well as significant reduction of oropharyngeal carriage of group A meningococci in vaccinated and unvaccinated individuals, demonstrating the vaccine's ability to generate herd protection and prevent group A epidemics.Conclusions. Lessons learned from this experience provide useful insights in how to guide and better prepare for future new vaccine introductions in resource-limited settings.

Tags

vaccine evaluation frameworkmeningococcal group Adisease incidencePsA-TTAfrica meningitis beltMESH: AdolescentMESH: AdultMESH: ChildMESH: Child, PreschoolMESH: Disease Transmission, Infectious+14

Licenses

http://creativecommons.org/licenses/by/info:eu-repo/semantics/OpenAccess

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