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Replication Data for: Lifelong malaria exposure drives B cell activation and post-transcriptional regulation while suppressing inflammatory transcriptional programs

Domaine:

healthcare

Type de record:

dataset
Créateur:
KimMwiMudMut
Éditeur:
KimNduThe
Éditeur:
Har
Hôte:avatar

This is a replication dataset for the manuscript titled: "Lifelong malaria exposure drives B cell activation and post-transcriptional regulation while suppressing inflammatory transcriptional programs ."

This dataset was generated as part of a study investigating immunological signatures associated with lifelong malaria exposure among healthy adult participants from Kenya. It includes data collected across multiple malaria transmission settings and comprises:

  • Baseline participant characteristics (e.g., age, sex, site)
  • Raw and processed cytokine measurements from plasma samples
  • Raw and normalised RNA-seq counts from peripheral blood mononuclear cells (PBMCs), including both unprocessed gene-level counts and counts normalised to counts per million (CPM)
  • An R Markdown file with annotated statistical code used for data processing and analysis

Visit

doi.orgdataverse.harvard.edu

Tags

Medicine, Health and Life SciencesChronic exposurepathogen exposureImmune activationImmune toleranceImmunomodulationImmune imprintingMalaria

Licenses

info:eu-repo/semantics/restrictedAccessCreative Commons Attribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/legalcode

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