In Nigeria society high premium is placed on child bearing. This has made childlessness to become
a socio-cultural problem. Couples are unnecessarily put under pressure to bear children so as to
secure genealogy. Childlessness, in Nigeria, normally attracts marital crisis, social disorder,
stigmatization, emotional stress, isolation and depression in marriage. In-vitro fertilization has
been discovered to be one of the ways to addressing infertility challenge. This study examines
resistance to in-vitro fertilization as a panacea to the challenge of infertility in Nigeria. The study
adopted descriptive research approach. Findings revealed that there are religious, cultural,
ethical, economic, psychological/social resistance to in-vitro fertilization as a panacea to the
challenge of infertility. The study concluded that in-vitro fertilization gives hope to couples faced
with infertility challenges, that infertility is seen through the lenses of traditional and religious
beliefs and this has become great obstacle to the acceptance of in-vitro fertilization as a solution
to the challenge of infertility. This work recommended that there is the need for reproductive
education, encouragement of seminars and conferences involving religious leaders, ethicists and
medical personnel in order for in vitro fertilization to be acceptable in Nigeria society.