Illicit substance use among youths remains a significant public health concern globally and in
Nigeria, particularly in urban centres such as Zaria. The increasing prevalence of psychoactive
substance use among young people has been associated with adverse outcomes including mental
health disorders, academic decline, violence, and social dysfunction. Despite existing control
efforts, there remains a gap in the use of structured, evidence-based early intervention strategies
for prevention and reduction of risky substance use behaviours. This study examined Screening,
Brief Intervention, and Referral to Treatment (SBIRT) as a preventive and early intervention
approach for reducing risky illicit substance use behaviours among youths. SBIRT is a
comprehensive public health model designed to identify individuals engaged in risky substance
use, provide brief motivational counselling, and refer severe cases for specialized treatment. The
study was anchored on the Transtheoretical Model of Behaviour Change, the Health Belief Model,
and Social Cognitive Theory, which collectively explain behavioural change processes, health
perceptions, and environmental influences on substance use. The study highlighted that SBIRT is
effective in promoting awareness of substance-related risks, enhancing readiness to change, and
reducing the frequency and intensity of substance use among youths. It further established that
integrating SBIRT into schools, community programmes, and primary healthcare settings can
improve early detection and intervention outcomes. However, challenges such as inadequate
trained personnel, limited treatment facilities, and weak referral systems may hinder effective
implementation in resource-constrained settings. The study concluded that SBIRT is a viable and
cost-effective strategy for addressing illicit substance use among youths in Nigeria. It
recommended the integration of SBIRT into educational and healthcare systems, capacity building
for service providers, and strengthening of referral networks to improve access to care.