Spirituality, culture, traditions, and other beliefs affecting cancer care vary with time. Today, in 2021, they are most affected by poverty and, more recently, by COVID-19 and lockdowns. This chapter discusses how, on three continents, beliefs, sometimes changing with time and circumstances, affect cancer care and access to curative or palliative services. It also explores how a person’s approach to cancer care is affected by country of origin, culture, traditions, spiritual beliefs, life experience, family, and community approaches, as well as by income and the availability of curative or palliative services. It is based on those countries where author A.M. has lived and worked on three continents—Southeast Asia, Europe, and Africa—and in seven countries—Ireland, the United Kingdom, India, Singapore, Malaysia, Nigeria, Kenya, and Uganda. It also draws on the lived experience in Africa of authors E.N. and G.N. A.M.’s experience of practicing, researching, and teaching medicine on three continents draws attention to why one approach does not fit all.