Data from end-of-period visit showing median (interquartile range) by dosing regimen in common concentration units. Serum TFV Cpre-dose, PBMC TFV-DP Cpre-dose, and cervicovaginal lavage include African clinical sites; other parameters are calculable only for US clinical sites. Rectal sponges are only from one US site. For values below the LLOQ,<[median LLOQ] is shown. Cervicovaginal lavage results were corrected for estimated average 20× dilution of 0.5 mL cervicovaginal fluid in 10 mL lavage fluid [11].