Supporting data for the chromosome-level genome assembly of the malaria vector Anopheles arabiensis
Domaine:
healthcareType de record:
dataset
Créateur:
ZamAvdLiaSha
Éditeur:
Gig
Hôte:
Anopheles arabiensis belongs to the An. gambiae complex and is among the major malaria vectors in Sub-Saharan Africa. However, a chromosome-level reference genome assembly for this medically important species is not yet available.
In this study, we produced de novo chromosome-level genome assemblies for both An. coluzzii and An. arabiensis using the long-read Oxford Nanopore sequencing technology and the Hi-C scaffolding approach.
We obtained a 256.8 Mbp assembly for An. arabiensis, consisting of three chromosome-scale scaffolds (X, 2, 3), complete mitochondrion, and unordered contigs identified as autosomal pericentromeric DNA, X pericentromeric DNA, and Y sequences. A comparison of our assembly with the existing assemblies for these species demonstrated that we obtained improved reference-quality genomes. Together, the new assemblies of An. coluzzii and An. arabiensis allowed us to identify genomic coordinates for the breakpoint regions of fixed and polymorphic chromosomal inversions.
This new chromosome-level assembly will facilitate functional and population genomic studies and the presented assembly pipeline will accelerate progress toward creating high-quality genome references for other disease vectors.
In this study, we produced de novo chromosome-level genome assemblies for both An. coluzzii and An. arabiensis using the long-read Oxford Nanopore sequencing technology and the Hi-C scaffolding approach.
We obtained a 256.8 Mbp assembly for An. arabiensis, consisting of three chromosome-scale scaffolds (X, 2, 3), complete mitochondrion, and unordered contigs identified as autosomal pericentromeric DNA, X pericentromeric DNA, and Y sequences. A comparison of our assembly with the existing assemblies for these species demonstrated that we obtained improved reference-quality genomes. Together, the new assemblies of An. coluzzii and An. arabiensis allowed us to identify genomic coordinates for the breakpoint regions of fixed and polymorphic chromosomal inversions.
This new chromosome-level assembly will facilitate functional and population genomic studies and the presented assembly pipeline will accelerate progress toward creating high-quality genome references for other disease vectors.
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