Digitalization facilitates more efficient communication and operations between firms, provided that businesses adopt and effectively utilize digital technologies. In developing countries, particularly in Africa, SMEs are facing significant challenges in e-commerce adoption. The studies conducted on e-commerce adoption in Africa are inadequate and fragmented with country-specific studies. This study used Technological-Organizational-Environmental factors framework and analyzed 22 peer-reviewed articles published from 2015 to 2024. The findings revealed that limited digital literacy and inadequate ICT infrastructure are the most significant technological factors affecting e-commerce adoption. Among organizational factors, top management support and commitment play a crucial role, while legal and regulatory factors, as well as security and privacy concerns, are key environmental factors influencing e-commerce adoption among SMEs in Africa. Thus, a collaborative approach involving various stakeholders in each country is essential for facilitating successful e-commerce adoption.