The study evaluated the effectiveness of anti-drug initiatives in Mutare City, focusing on adolescent outcomes. A mixed-methods design was employed, incorporating surveys, interviews, questionnaires, and focus groups to gather extensive and diverse data from a sample of 300 adolescents (150 males and 150 females) from Sakubva, Dangamvura, and Chikanga high-density suburbs. The study explored the impact of current anti-drug initiatives on adolescents' knowledge, attitudes, and behaviours related to drug use, as well as their social and environmental factors. Grounded in Social Learning Theory and Ecological Systems Theory, the study revealed that existing policies and programmes had limited impact, with many citing social and environmental factors as primary influences on their behaviours. A significant gap in addressing these factors was identified, highlighting the need for a comprehensive and multifaceted approach. The recommendations included a tailored strategy, incorporating evidence-based prevention, counselling, and community engagement to effectively address drug abuse among adolescents in Mutare City.