Food insecurity and malnutrition remain a global challenge, with poverty being a main cause. Recent events with global repercussions, including the COVID-19 pandemic and Russia’s war of aggression in Ukraine, have created shock waves that disrupt global food trade and inflate prices worldwide. Regional conflicts and environmental megatrends exacerbate the fragility of food systems. In sub-Saharan Africa, droughts and armed conflicts are especially challenging. This study provides a synthesis of rigorous impact evaluations on the effectiveness of capacity strengthening interventions in the area of food security and nutrition with a regional focus on sub-Saharan Africa.