An analysis of pharmacy practice regulation in Ordinances and Acts could aid understanding of the origins and evolution of pharmacy practice regulation in Ghana. This study analyses the name, duties, membership and chair of governing bodies and requirements needed for pharmacy practice between 1892 and 2013. Data were sourced from Ordinances, Acts, Hansard and key informants. The governing body started as a Board of Examiners with only medical practitioners. Pharmacists were included in 1946, with a pharmacist chairing since 1961, and medical practitioners were excluded in 1994. The current Act 857 prescribes a wider membership of the Pharmacy Council, including three lay members nominated by the Minister for Health. Duties of the governing body were expanded from conducting examinations to developing management structures to regulate pharmacy practice. Pharmaceutical Historian, vol. 50, no. 4, p. 97