Scientific data 10(1), 87 (2023). doi:10.1038/s41597-022-01811-7 In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinatedthree large-scale psychological studies to examine the effects of loss-gain framing, cognitivereappraisals, and autonomy framing manipulations on behavioral intentions and affectivemeasures. The data collected (April to October 2020) included specific measures for eachexperimental study, a general questionnaire examining health prevention behaviors andCOVID-19 experience, geographical and cultural context characterization, and demographicinformation for each participant. Each participant started the study with the same generalquestions and then was randomized to complete either one longer experiment or two shorterexperiments. Data were provided by 73,223 participants with varying completion rates.Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processedformats to facilitate re-use and further analyses. The dataset offers secondary analyticopportunities to explore coping, framing, and self-determination across a diverse, globalsample obtained at the onset of the COVID-19 pandemic, which can be merged with othertime-sampled or geographic data. Published by Nature Publ. Group, London