This dataset contains survey data collected from employees of Small and Medium-sized Enterprises (SMEs) in Ghana for a study on biological thinking in organizational settings. The data include responses relating to biological thinking constructs and associated workplace factors. Data were collected using structured questionnaires administered to SME employees across Ghana. All personal identifiers have been removed to ensure participant confidentiality. The dataset is intended to support research on biological thinking and its implications for organizational behavior and management practices in SMEs.