Trauma is a pervasive yet underrecognized public health crisis often shaped by structural and historical violence. Despite its embodied, social, and intergenerational manifestations across the life course, trauma remains largely unrecognized within public health frameworks. Existing public health approaches prioritize discrete social determinants while neglecting trauma as both an outcome and a driver of inequity. This invisibility is context dependent, such that trauma is normalized and expected in settings marked by chronic violence and deprivation, yet, determined exceptional elsewhere. Trauma is thus one of the most veiled syndemic contributors globally, silently undermining social functioning and population well-being. We propose that trauma, mental health disorders, and the structural violence are synergistically linked, such that trauma constrains occupational and social participation, while poverty, environmental exposures, and systemic exclusion perpetuate traumatic harm across generations. In African contexts, colonialism constitutes a distinct and enduring form of structural violence, with post-colonial inequities representing its traumatic vestiges. Focusing on post-conflict Angola as a case example, we contend that decolonization must be understood as a public health imperative. The aim of this Viewpoint is to conceptualize trauma, mental health, and structural violence through a syndemic framework. We argue that healing trauma and eradicating poverty are inseparable from restoring justice, necessitating trauma-informed, structurally grounded policy and programmatic responses.