This dataset contains the anonymised survey responses used in the study titled “Understanding E-Tendering Adoption in Construction Procurement: The Interplay of Strategic Interventions and Contextual Barriers.” The data were collected from 95 construction industry practitioners involved in the tendering process in Ghana. The dataset includes respondents' demographic characteristics and responses relating to e-tendering adoption, contextual barriers, strategic interventions, and procurement performance. The data were analysed using SPSS 28.0 for descriptive statistics and one-sample t-tests, and SmartPLS 4.0 for Partial Least Squares Structural Equation Modelling (PLS-SEM). The dataset supports the empirical analyses and findings reported in the manuscript.