This chapter examines the concepts and issues of SME techno-entrepreneurship in ICT clusters. An integrative literature review was adopted and three purposively selected ICT clusters were observed. The chapter provides a conceptual framing of techno-entrepreneurship practices and identifies attributes of SME techno-entrepreneurship in Nigeria, its relevance to the ICT ecosystem growth as well as national development. The chapter identifies a frugal mindset, frugal processes, networking, innovative behaviour, and frugal outcome as key attributes of SME techno-entrepreneurs operating out of ICT clusters. By linking techno-entrepreneurship with frugal innovation, the chapter further proposes a model of SME techno-entrepreneurial practices in ICT clusters which highlights the various stages and processes of cluster SME techno-entrepreneurship. The paper concludes with a section on challenges and opportunities of SME techno-entrepreneurship in Nigeria.