Logo Lanfrica
  • Accueil
  • Atlas
  • Analyses
  • Documentation
  • Sign in

© 2026 Lanfrica. Tous droits réservés. Tous les droits d'auteur des ressources affichées sur le site Web Lanfrica appartiennent aux détenteurs de droits d'auteur d'origine, sauf indication contraire explicite.

Vaccine-Induced Seroreactivity Impacts the Accuracy of HIV Testing Algorithms in Sub-Saharan Africa: An Exploratory Study

Domaine:

healthcare

Type de record:

paper
Créateur:
FraAliSarNel
Éditeur:
MDP
Hôte:
The detection of vaccine-induced HIV antibody responses by rapid diagnostic tests (RDTs) may confound the interpretation of HIV testing results. We assessed the impact of vaccine-induced seroreactivity (VISR) on the diagnosis of HIV in sub-Saharan Africa. Samples collected from healthy participants of HIVIS and TaMoVac HIV vaccine trials after the final vaccination were analyzed for VISR using HIV testing algorithms used in Mozambique and Tanzania that employ two sequential RDTs. The samples were also tested for VISR using Enzygnost HIV Integral 4 ELISA and HIV western blot assays. Antibody titers to subtype C gp140 were determined using an in-house enzyme-linked immunosorbent assay (ELISA). The frequency of VISR was 93.4% (128/137) by Enzygnost HIV Integral 4 ELISA, and 66.4% (91/137) by western blot assay (WHO interpretation). The proportion of vaccine recipients that would have been misdiagnosed as HIV-positive in Mozambique was half of that in Tanzania: 26.3% (36/137) and 54.0% (74/137), respectively, p < 0.0001. In conclusion, the HIV RDTs and algorithms assessed here will potentially misclassify a large proportion of the HIV vaccine recipients if no other test is used. Increased efforts are needed to develop differential serological or molecular tools for use at the point of care.

Visit

doi.org

Licenses

https://creativecommons.org/licenses/by/4.0/

Similaires

HIV misdiagnosis in sub‐Saharan Africa: performance of diagnostic algorithms at six testing sitesDesigning HIV Testing Algorithms Based on 2015 WHO Guidelines Using Data from Six Sites in Sub-Saharan AfricaAccuracy of self-reported HIV-testing history and awareness of HIV-positive status in four sub-Saharan African countriesHIV-associated nephropathy: Protocol and rationale for an exploratory genotype-phenotype study in a sub-Saharan African populationFamily Physician Perceptions of Climate Change, Migration, Health, and Healthcare in Sub-Saharan Africa: An Exploratory StudyThe effect of HIV counselling and testing on HIV acquisition in sub-Saharan Africa: a systematic review

HIV misdiagnosis in sub‐Saharan Africa: performance of diagnostic algorithms at six testing sites

Abstract Introduction : We evaluated the diagnostic accuracy of HIV testing algorithms at six prog

Designing HIV Testing Algorithms Based on 2015 WHO Guidelines Using Data from Six Sites in Sub-Saharan Africa

ABSTRACT Our objective was to evaluate the performance of HIV testing algorithms based o

Accuracy of self-reported HIV-testing history and awareness of HIV-positive status in four sub-Saharan African countries

Background: In many countries in sub-Saharan Africa, self-reported HIV testing

HIV-associated nephropathy: Protocol and rationale for an exploratory genotype-phenotype study in a sub-Saharan African population

Background HIV-positive persons of African descent are disproportionately affected by chronic kidn

Family Physician Perceptions of Climate Change, Migration, Health, and Healthcare in Sub-Saharan Africa: An Exploratory Study

Although family physicians (FPs) are community-oriented primary care generalists and should be the e

The effect of HIV counselling and testing on HIV acquisition in sub-Saharan Africa: a systematic review

Objectives Annually, millions of people in sub-Saharan Africa (SSA) receive HIV