Background: Sub-Saharan Africa (SSA) faces a deepening wastewater management crisis, with
less than 10% of generated wastewater treated before environmental discharge. Conventional
treatment infrastructure is inadequate, underfunded, and energy-intensive, demanding innovative,
context-adapted solutions. Nanotechnology and bioremediation have independently
demonstrated high pollutant removal efficiency globally but remain poorly integrated within
SSA's water sector.
Objective: This systematic review critically evaluates the current evidence on nanotechnologybased and bioremediation-based wastewater treatment approaches, assesses their adaptability to
SSA's socioeconomic and environmental realities, and proposes a hybrid nano-bioremediation
framework for the region.
Methods: A structured literature search was conducted across PubMed, Scopus, Web of Science,
and Google Scholar using PRISMA guidelines. Studies published between 2020 and 2025
addressing nanotechnology, bioremediation, or integrated hybrid systems for wastewater
treatment with SSA applicability were eligible for inclusion. Thirty peer-reviewed articles were
synthesised narratively