Workplace stress among health educators is becoming an emerging issue in the global world today, and its effect becomes more pronounced in the Nigerian setting. This study aims to determine the impact of workplace stressors on nurse educators in the southeastern universities' nursing departments in Nigeria. A cross-sectional study design was used; a purposeful sampling technique was employed to select 10 accredited universities offering nursing in south-east Nigeria, and a census method was adopted to arrive at a sample size of one hundred and seventy-six (176) based on the small size of the nurse educators in the selected universities. Data was collected with a self-administered questionnaire, collated and analysed using the Statistical Package for Social Sciences (SPSS) version 26. The democratic managerial style had 148 (84.09%) acceptances in this study; the respondents (172, 97.7%) accepted that interpersonal relationships with colleagues can influence job stress and that lack of special training or skills is not a challenge to nurse educators in the selected university nursing departments. The hypothesis testing revealed that the calculated p-value was less than the 0.05 significance; hence, all the work stressors tested have a significant relationship with job stress.