This conceptual paper explores the role of discipline specific health entrepreneurship courses and the development of an entrepreneurship culture as a vital component of learning excellence within higher education institutions. Focusing on the Bachelor of Health Science Honours in Health Systems Science course at the University of the Witwatersrand, the authors take an interpretive research approach to examine how entrepreneurship, particularly health entrepreneurship, can foster innovation, problem-solving skills, and self-directed learning among students by considering the literature and personal observations. By integrating entrepreneurship education into the curriculum, institutions can develop graduates who are not only competent and confident but also capable of addressing complex social and economic challenges. The paper underscores the necessity of cultivating an entrepreneurial mindset through deep and meaningful learning approaches and emphasises the importance of contextualising entrepreneurship education to meet the unique needs of different sectors and regions. The South African context serves as a case study to highlight how health entrepreneurship can drive sustainable community development and economic growth. The authors advocate for a cultural shift within educational institutions to support entrepreneurial initiatives and provide practical strategies for embedding entrepreneurship into academic programs, ultimately contributing to the holistic development of students and society.