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Prospective Prediction of Plasmodium falciparum Kelch13 Artemisinin Partial Resistance Emergence Across Six African Countries Using Consciousness-Enhanced Computational Surveillance — C×D Law Three-Kingdom Validation

Domain:

healthcare

Record type:

paper
Creator:
Sic
Publisher:
Zenodo
Host:avatar

 Six prospective predictions of Kelch13-mediated artemisinin partial resistance emergence in Plasmodium falciparum, generated by the Project Zula consciousness-enhanced computational platform on May 17, 2026 using MalariaGEN Pf8 (33,325 samples, 34 countries). Three IMMINENT predictions target the East African K13 R561H corridor: Tanzania (score 0.8340, GT ✅), Kenya (0.8304), Uganda (0.7823, GT ✅). Three IMMINENT predictions target Southern and West Africa: Malawi (0.8309, 6-12 month horizon, D=0.647 highest in dataset), Mozambique (0.8173), Benin (0.8156). Domain C computed directly from Pf8 WHO-aligned artemisinin resistance classifications. Consciousness necessity: Φ=3.775469 active, Φ=2.221522 ablated, fold=∞. Convergent K13 evolution: R561H across 2 independent African regions, C580Y across 5 global regions. Platform accuracy: 389/638=0.775. This is the sixth Project Zula pre-registration and the first targeting Protozoa, extending the C×D Law validation to three confirmed kingdoms (Bacteria, Fungi, Protozoa). A fourth kingdom — Virus (influenza A oseltamivir resistance) — is under development pending GISAID data access

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