Replication Data for: Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV

This is a replication dataset for the manuscript titled: "Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV."

In sub-Saharan Africa, a proportion of children hospitalised with severe malnutrition (SM) also have HIV infection (HIV-SM). Children with HIV-SM have poorer clinical outcomes than children with SM alone. They face high mortality both during and after hospitalisation, have impaired nutritional recovery post-hospitalisation and have increased relapse recovery. Despite this elevated risks biological mechanisms underlying the risk remain unclear. This study is nested with the CHAIN cohort sites in Kenya, Uganda, Malawi and Burkina Faso. The current study aimed to understand how HIV influences post-discharge growth among children with HIV-SM in sub-Saharan Africa. In the current study proteins from plasma collected from children at hospital discharge were quantified using SomaScan assay. Over 7300 proteins were quantified. The analysis also included anthropometric measurements e.g., mid-upper arm circumference, weight-for-age, weight-for-height and height-for-age scores taken at discharge, 45-days post-discharge, 90-days post-discharge, and 180-days post-discharge. Demographic data included sex, age, site of enrolment.

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