Africa faces the greatest threat due to climate change. This research stems from the growing concerns for buildings in sub-Saharan Africa to respond to climate change issues by addressing the carbon emissions arising from using high embodied energy materials in building constructions. It investigates the use of timber and aerated brick as suitable replacements for concrete in the tropics for improved indoor comfort and reduced global warming impact (GWI). The investigation relies on Meteonorm and Climate Consultant for weather data collection, DesignBuilder for the case building simulations and One-Click LCA software for lifecycle assessment. The results show that the timber building has the least CO2 emissions but with a significant threat of being very expensive. The timber/brick alternative accounts for the most improved operative temperature, while the concrete building has the highest emissions during the buildingâs lifecycle but with the least impact in the maintenance and end-of-life stages.