Gene drive parameter space satisfying a > 50% reduction in clinical malaria incidence for defined durations.

Windows-of-protection (WOPs) are depicted for two country settings (Burkina Faso and Kenya, defined by their seasonal profile in Fig 1B and intervention coverage profile in Table 1) and three transmission settings (entomological inoculation rates, or EIRs, of 100, 50 and 10 infective bites per person per year). Gene drive parameters explored include: i) the fitness cost associated with being homozygous for the gene drive (H) allele, ii) the probability of mosquito-to-human transmission for mosquitoes having the H allele, iii) the fitness cost associated with being homozygous for the out-of-frame or otherwise costly B resistance allele, and iv) the proportion of generated resistance alleles that are in-frame and cost-free (R). The homing rate parameter was fixed at 0.95, since proposed outcome criteria were found to be least sensitive to its value within a feasible range.