Minimum gene drive parameter values satisfying clinical malaria incidence window-of-protection greater than three years.

Lines depict values of s_H (H allele fitness cost) and b_H (mosquito-to-human infection probability for mosquitoes having the H allele) below which the clinical malaria incidence window-of-protection exceeds three years, and above which it does not. Each line depicts a distinct set of resistance allele parameters - i.e., s_B (B resistance allele fitness cost) and p_R (proportion of R resistance alleles). The homing rate parameter, h, is fixed at 0.95. Threshold parameter values are depicted for two country settings (Burkina Faso and Kenya, defined by their seasonal profile in Fig 1B and intervention coverage profile in Table 1) and three transmission settings (entomological inoculation rates, or EIRs, of 100, 50 and 10 infective bites per person per year).