This chapter interrogates the potential of women entrepreneurship as an economic strategy to address unemployment and job creation. The chapter focusses on creative industry to demonstrate that creativity and innovations can activate entrepreneurship among women in South Africa. It is through entrepreneurship that entrepreneurs transform their innovative and creative ideas into business enterprises and job creation. Although female entrepreneurship for economic development is recognised internationally, it lags behind those of men especially in the number of women business owners and the size of businesses including access to economic resources. The chapter argues that entrepreneurs are central in boosting the economy and the optimal use of their skills, innovative new ideas that sustain entrepreneurial creative projects. The chapter makes use of a visual profile, participant observation, case studies, and face-to-face interviews with women involved in creative industries such as bead making, pottery, traditional dress-making, and traditional dance.